Flying with an EpiPen: What You Need to Know

Traveling with severe allergies? Your EpiPen is your lifeline, but navigating airports and flights can feel stressful.
Don’t worry—this guide has everything you need from TSA in this country, to customs rules overseas, to handling in-flight emergencies. For a complete view on flying with medications both domestically and abroad, read our comprehensive guide to Flying with Medication.
Let’s dive in so you can travel with confidence.
1. TSA Guidelines for Flying with an EpiPen
1.1 TSA’s Rules for Medication-Filled Devices
Your EpiPen is exempt from the TSA’s 3.4-ounce liquid rule. You don’t have to worry about putting it in a quart-sized bag with nor do you need to worry about volume restrictions. TSA also allows unlimited medically necessary items, including EpiPens.
While not mandatory, it’s a good idea to declare your EpiPen during the security check.
KEEN TIP: Having your EpiPen clearly labeled or in its original packaging with a prescription label can smooth the process, but it’s not required.
1.2 Carrying Your EpiPen in Carry-On vs. Checked Baggage
Keep your EpiPenp in your carry-on luggage in a small, easily accessible bag that you can keep close, such as a purse or backpack. You want to have it within reach during your flight in the event of an allergic reaction.
Never pack an EpiPen in checked baggage. Checked baggage is not temperature-controlled, and access during a flight is not possible. Carrying your EpiPen in the cabin ensures it’s stored in a temperature-controlled environment and is within reach.
1.3 Do You Need a Doctor’s Note for Your EpiPen?
For TSA purposes, a doctor’s note is not required but carrying a doctor’s letter or the prescription label can help if questions arise from either the airline or TSA staff.
A doctor’s not and original packaging are highly recommended for international travel, as some countries have stricter rules about medications. In addition, having documentation translated into the local language can help avoid issues.
1.4 Can You Bring Multiple EpiPens on a Flight?
Yes, you can bring multiple EpiPens on a flight, and it’s recommended for backup in case of loss, damage, or additional allergic reactions.
KEEN TIP: Store your EpiPens in different locations, such as one in a carry-on bag and another in a purse or jacket pocket, so they always have one within easy reach.
2. Preparing Your EpiPen for Air Travel
2.1 How to Pack Your EpiPen to Avoid Damage
To protect your EpiPen, use a hard-shell case to prevent physical damage and accidental activation and store it in a zippered pouch with documents like a doctor’s note, label and usage instructions.
2.2 Ensuring It Stays at the Right Temperature

EpiPens should be kept between 59°F and 86°F (15°C to 30°C). The cabin temperature is typically safe, but in hot climates, using an insulated case is vital.
The first time my mom traveled with an EpiPen (she was allergic to red ants and they always seemed to find her), she was on a flight with my dad that had a three-hour unplanned layover in Antigua because of an engine issue. Everyone left the plane; some went to a local hotel for a cold drink, others, like my folks, went into town to shop. Her EpiPen was exposed to very high temperatures as they walked in the hot sun, making it unusable, so she had to quickly arrange for a new prescription when she got to her hotel.
Consider using a Frio case or similar insulated bag designed for medications. Tuck in a small thermometer to monitor the temperature.
TIP FROM MEDICAL EXPERTS: If your EpiPen gets too hot or cold, inspect the liquid for discoloration or cloudiness; if you notice either of these changes, it could be ineffective and should be replaced immediately.
3. Traveling Internationally with an EpiPen
3.1 Customs Requirements for Traveling with an EpiPen
When traveling internationally, you’ll need the following:
- Documentation: Have a doctor’s note or prescription detailing the medical necessity of your EpiPen. If possible, have it translated into the official language of your destination country.
- Original Packaging: Keep your EpiPen in its original packaging, which includes prescription information. This helps verify it as a legitimate medical device.
- Declaration at Customs: Upon arrival at your destination, declare your EpiPen along with other medications. While it is typically permissible, some countries may have stricter regulations.
- Research Before Departure: Check the specific rules of the countries you are visiting, as some restrict the import of medications, even those deemed essential.
3.3 Tips for Navigating Customs with an EpiPen
Navigating customs can vary depending on the country’s regulations, but there are ways to ensure a smooth process:
- Use a Clear, Labeled Case: Keep your EpiPen in a transparent, clearly labeled medical bag, making it easy for customs officers to identify and inspect. This lessens the chance they will have to remove it; if you don’t have a clear case, place it in a zip lock bag.
- Know the Local Regulations: Research whether your destination country restricts or prohibits specific medications, including epinephrine injectors, even if medically necessary.
- Be Prepared to Explain: Customs officials may ask you questions about your EpiPen. Clearly and politely explain that it is a life-saving medical device necessary for emergencies due to severe allergies. This is where a translated letter from your doctor will help.
- Use Airport Medical Assistance: If you encounter issues with customs clearance, request help from airport medical assistance staff. They are often familiar with travelers carrying medications and can offer support
KEEN TIP: Keep a list of key medical phrases related to allergies and epinephrine injection in the local language. This can be helpful if you encounter language barriers when communicating with customs officers.
4. Passing Through Security with an EpiPen
4.1 What to Expect at the Checkpoint
When flying with an EpiPen, the experience should be straightforward, but it helps to know what to expect:
- Let the officer know you are carrying an EpiPen and place it in a separate bin with documentation.
- Your EpiPen will usually go through the X-ray scanner, just like your other carry-on items.
- If you prefer not to expose your EpiPen to X-ray screening, you can request a manual inspection. However, be prepared to answer questions or show supporting documents, like a prescription label or doctor’s note.
4.2 Quick Tips for Getting Through Security Smoothly
- Keep It Accessible: Pack your EpiPen in an easily reachable part of your carry-on, so you can quickly remove it during screening.
- Use a Medical Pouch: Store your EpiPen in a labeled medical pouch that indicates it contains emergency medication, making it recognizable to TSA officers.
- Bring Extra Supplies: In addition to your EpiPen, carry other essentials like antihistamines, sterile wipes, and a small packet of tissues in your medical kit. This can help you manage minor symptoms if they arise during the flight.
4.3 What to Do if TSA or Customs Agents Question Your EpiPen

- Explain Clearly: State that the EpiPen is a life-saving medical device needed for emergencies due to severe allergic reactions.
- Provide Documentation: If asked, show your prescription label, doctor’s note, or any other supporting documents.
- Request a Supervisor: If issues persist, you can request to speak to a TSA supervisor, who may have a better understanding of medical devices like EpiPens.
- Know Your Rights: TSA guidelines allow passengers to carry medically necessary items, including EpiPens. If you are flying overseas, you have the right to bring it on board, provided it complies with the basic security rules of your destination country.
5. What to Do in Case of an Allergic Reaction During a Flight
5.1 How to Notify Flight Attendants of Your EpiPen
If you have a history of severe allergies and are flying with an EpiPen, it’s a good idea to notify flight attendants as soon as you board. Here’s why:
- Preparation: Flight attendants are trained to handle medical emergencies and can assist if you need to use your EpiPen mid-flight.
- Informing the Crew: Let them know about your allergy and where your EpiPen is stored, so they can help retrieve it quickly if necessary.
5.2 Request Allergy-Friendly Accommodations from the Airline
Here are some options you can exercise:
- Pre-boarding: By boarding early you can wipe down your seat and surrounding area to minimize exposure to allergens.
- Allergy Announcements: If you request it, the airline can announce your allergy (you remain anonymous) and ask passengers to avoid consuming certain foods.
KEEN TIP: Keep disinfectant wipes handy to clean your tray table, armrests, and seatbelt buckle, as these surfaces can harbor allergens.
5.3 Communicating with Fellow Passengers About Potential Allergens
If you have severe allergies to common food items like nuts or shellfish, consider notifying the passengers seated near you:
- Be Polite: A simple, polite request such as, “I have a severe allergy to nuts. Would you mind not eating peanuts during the flight?” can often yield a positive response.
- Offer Alternatives: If you have extra allergy-friendly snacks, offer them to nearby passengers as a friendly gesture.
5.4 Administering Your EpiPen Mid-Flight: Key Steps
If you experience an allergic reaction during the flight, quick action is essential:
- Stay Calm: Alert the flight attendants immediately and let them know that you may need to administer your EpiPen.
- Retrieve Your EpiPen: Access your EpiPen from your carry-on or personal bag.
- Follow These Steps from Healthline.com to Use Your EpiPen:
- Prepare: Hold the EpiPen in your fist with the orange tip pointing down. Remove the blue safety cap.
- Administer: Place the orange tip on your outer thigh, press firmly, and hold for 3 seconds.
- After Injection: Massage the injection site for 10 seconds and inform the crew to initiate emergency procedures.
IMPORTANT: After administering the EpiPen, notify the flight attendants so they can initiate any necessary emergency procedures, such as requesting medical assistance upon landing.
6. Additional Considerations for a Smooth Flight
6.1 Pack Allergy-Friendly Snacks
If you have food allergies, take control of what you eat by packing non-perishable, allergy-friendly snacks.

- Nut-free granola bars
- Gluten-free crackers
- Dried fruit
6.2 Check Airline Policies for Peanut-Free or Allergy-Friendly Flights
If you have an allergy to peanuts, some airlines are more sensitive than others to passengers with allergies.
- Contact the airline’s customer service: Inquire about peanut-free or allergy-friendly flights and what steps the airline can take to ensure your safety.
- KEEN TIP: I typically chat with an airline through their mobile app. It is easier than getting someone on the phone. Initially, you start with a chatbot but after a few tries answering your concern unsuccessfully, they will offer to connect you to a live person.
- Check Connecting Flights: If you have international layovers, verify the allergy policies of connecting airlines as well.
6.3 Managing Your Allergies on Long-Haul Flights: 5 Tips
- Inform Flight Attendants: Communicate your allergies clearly before takeoff.
- Use a Face Mask: Wearing a mask can help filter airborne allergens.
- Bring Plenty of Snacks: Have enough snacks to last the entire flight, as relying on in-flight meals can be risky.
- Use Wipes for Cleaning: Wipe down your seating area to minimize exposure.
- Communicate with Passengers: Politely request those nearby to avoid consuming foods you’re allergic to.
6.4 What to Do If Your EpiPen Is Lost or Damaged During Travel
- Check Airport Pharmacies: Some larger international airports have pharmacies that stock emergency medications like EpiPens.
- Contact Your Doctor: If no replacement is available, contact your healthcare provider for advice. They may be able to call in a prescription to a local pharmacy.
6.5 Carry a Medical Alert Bracelet or ID Card
Wearing a medical alert bracelet or carrying an ID card detailing your allergies is important:
- Why: In the event of an emergency or if you lose consciousness, it helps responders quickly understand your condition.
- What to Include: List your allergies, medical conditions, and emergency contacts.
6.6 Bring Backup Medications
Besides a second EpiPen, consider carrying:
- Antihistamines: For managing minor reactions.
- Other Prescribed Allergy Medications: As recommended by your doctor.
6.7 Research Your Destination’s Medical Facilities

Before you travel, research nearby hospitals, clinics, and pharmacies at your destination. Ensure they can handle allergic reactions or anaphylaxis.
6.8 Have a Travel Companion Who Knows How to Use an EpiPen
In certain cases, you may not be able to self-administer the EpiPen. Teach your travel companion how to use it before you board; they can always access the Healthline link for how to use it in section 5.4 above.
7. Frequently Asked Questions (FAQ’s)
7.1 Can I request special seating on a flight if I have severe allergies?
Yes, you can request seating away from food prep areas or where fewer passengers consume allergens. Contact the airline in advance to explain your needs, and ask if they offer any specific accommodations for passengers with severe allergies.
7.2 What should I do if I have an allergic reaction and use my EpiPen during a flight?
If you need to use your EpiPen mid-flight due to an allergic reaction:
- Alert the Flight Attendants: Immediately inform flight attendants that you’ve used your EpiPen. They will provide assistance, including calling for any medical personnel on board.
- Notify the Pilot: Flight attendants will inform the pilot, who may arrange for an emergency landing if needed.
- Seek Further Medical Attention: After using an EpiPen, further medical evaluation is necessary, as secondary reactions can occur. The airline will have paramedics or medical personnel waiting upon landing to assist you.
7.3 Are there alternative auto-injectors I can bring instead of EpiPen?
Yes, there are alternatives to EpiPen, such as Auvi-Q and Adrenaclick. These function similarly and can be used if you have a prescription for them.
7.4 What should I do if my EpiPen is confiscated at customs?
If your EpiPen is (erroneously) confiscated by customs officials:
- Stay Calm: Explain that it’s a medically necessary device for severe allergies.
- Show Documentation: Present your doctor’s note, prescription label, or translated medical documents to clarify its necessity.
- Contact Local Authorities: If your EpiPen is held despite your explanation, ask for a supervisor. If you are still unsuccessful at retrieving it, contact the U.S. Embassy for the country you are arriving in or local health authorities for support in obtaining a replacement.
7.5 Can I carry an EpiPen through all international airports?
Yes, you can generally carry an EpiPen through international airports, but you must follow the regulations of the specific country.
- Best Practices: Research the entry rules of your destination country, as some nations have stricter requirements for bringing medications.
- Documentation: Carry proper documentation, including translated medical records, to facilitate customs clearance.
7.6 How should I store my EpiPen if I’m traveling to a hot or cold climate?
When traveling to extreme climates:
- Hot Climate: Use an insulated case with a small ice pack to keep your EpiPen within the recommended temperature range (59°F to 86°F).
- Cold Climate: Wrap the EpiPen in thermal sleeves or store it close to your body to prevent freezing.
- Check Regularly: Monitor the EpiPen’s temperature using a small thermometer to ensure it remains effective.
7.7 Is it possible to bring multiple EpiPens on long-haul flights?
Yes, carrying multiple EpiPens on long-haul flights is allowed and encouraged.
- Why: Having backups ensures you’re prepared in case of an allergic reaction, loss, or damage during transit.
- How to Pack: Distribute them across your carry-on luggage, purse, or jacket pocket for easy access.
7.8 Are there any pre-screening programs to help expedite security checks for passengers with medical devices?
Yes, programs like TSA PreCheck and Global Entry can expedite security screenings:
- Benefits: Passengers enrolled in these programs often experience quicker security checks and shorter wait times, which can reduce stress for those carrying medical devices like EpiPens.
- How to Enroll: Apply online and schedule an interview to join the programs. Memberships are valid for several years.
7.9 How can I prepare for a medical emergency if I’m traveling alone?
If you’re traveling alone, take these extra precautions:
- Carry a Medical Alert Bracelet: Wear a medical alert bracelet that identifies your allergies and need for an EpiPen.
- Use a Translation App: Have a medical translation app handy to communicate with local medical personnel if needed.
- Inform the Airline: Let the airline know during check-in that you have severe allergies and carry an EpiPen. They can add a note to your boarding pass.
8. Wrap Up
Flying with an EpiPen doesn’t have to be stressful, if you’re prepared. Knowing how to pack it, navigating TSA and customs smoothly, and being ready for in-flight emergencies can make all the difference.
Review this checklist before traveling:
- Pack multiple EpiPens and other allergy medications.
- Carry a doctor’s note and translated documentation.
- Use an insulated case to maintain temperature.
- Notify flight attendants upon boarding or when booking your ticket.
- Research destination-specific medication regulations.
- Have emergency contacts and a medical plan ready.
By taking these steps, you can travel confidently with your EpiPen and enjoy your journey.